Design and evaluation of voriconazole loaded solid lipid. This study assessed the feasibility of using solid lipid nanoparticles for ocular delivery of voriconazole. Formulation and characterization of hydrochlorothiazide solid. Slms combine the advantages of different traditional carriers. Preparation, characterization and evaluation of moisturizing and uv protecting effects of topical solid lipid nanoparticles 685 and zeta potential of the sln formulations. Microvesicles ectosomes, or microparticles are a type of extracellular vesicle ev that are released from the cell membrane.
Systemic administration of voriconazole is associated with side effects including visual and hepatic abnormalities. Slns act as a new colloidal drug carrier for intravenous applications. These lipid microparticles are dispersed in a cold surfactant solution yielding a presuspension and homogenized at or below room. The purpose of this study was to improve the solubilization, bioavailability, and permeability of hydrochlorothiazide hctz by the formulation and characterization of hctz solid lipid microparticles slms based on fat derived from irvingia gabonensis var.
Formulation, preparation, characterisation, drug release. Us20120128777a1 compositions containing lipid micro or. Formulation and evaluation of acyclovir sodium solid lipid microparticles anantha naik nagappa, gaurav agarwal, vinuth chikkamath, shilpi agarwal, rekha rani and pk karar date of receipt 122016 date of revision 15122016 date of acceptance 27122016 address for correspondence scs college of pharmacy, harapanahalli5831, karnataka, india. Formulation and release characteristics of zidovudine bioline.
The lipid matrix itself determines the particles pharmaceutical properties as it is the structure that stores, transports and releases the drug. Solid lipid nanoparticles sln are a new generation of drug delivery systems being exploited for several drugs since the nineties. An effective lipid based technology for controlled drug delivery. Voriconazole is a secondgeneration antifungal agent with excellent broad spectrum of antifungal activity commercially available for oral and intravenous administration. Solid lipid microdispersions slms based on pegylated solidified. The drug containing solid lipid is milled bymeans of mortar or ball mill to micron size 50100 micron and these microparticles aredispersed in chilled emulsifier solution yielding a presuspension. Rizatriptan loaded sln were prepared by modified solvent injection method and characterized for shape, surface morphology, particle size, and drug entrapment. Due to their unique size dependent properties, lipid nanoparticles offer possibilities to develop new therapeutics.
Microemulsion based method slns can be produced by microemulsification of molten lipids, as the internal phase and subsequent dispersion of the microemulsion in aqueous medium under mechanical stirring. Specific objectives were to develop hollow solid lipid micro and nanoparticles using scco 2 technology, and to load the hollow solid lipid micro and nanoparticles with essential oil to develop food grade freeflowing powder. Solid lipid nanoparticles possess a solid lipid core matrix that can solubilize lipophilic molecules. All components were weighted into sealed containers and heated to 80 c. Slns combine the advantages and avoid the drawbacks. Solid lipid nanoparticles sln are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery and research. Solid lipid nanoparticles authorstream presentation. Then the drug lipid mixture is rapidlycooled either by means of liquid nitrogen or dry ice. Solid lipid nanoparticles and polymeric nanocapsules are carrier systems that offer advantages including changes in the release profiles of bioactive compounds and their transfer to the site of.
Slns are colloidal carriers developed in the last decade as an alternative system to the existing traditional carriers emulsions, liposomes and polymeric nanoparticles. Solid lipid nanoparticles slns serve as an alternative carrier system for traditional colloidal carriers like polymeric microparticles, nanoparticles, liposomes and emulsions. Formulation and evaluation of acyclovir sodium solid lipid. The term coacervationwas suggested for the first time by two dutch scientists38. The invention is related to compositions which can be used as dermal formulations for supporting the skin to restore normal conditions in case of e. Solid lipid nanoparticles as colloidal drug carrier systems antonio j. Production, characterisation and release profiles, food research international on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. These lipid nanoparticles are known as solid lipid nanoparticles slns, which are attracting wide attention of formulators worldwide 2. Solid lipid nanoparticles sln, colloidal drug carriers, homogenization, tem, pcs, biodistribution, targeting. The resultant substance is then ground to obtain lipid microparticles 50100. First, the advantages of slms compared with other drug carrier systems are listed. Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research, as well as in other varied sciences. Formulation and evaluation of solid lipid nanoparticle sln. Solid lipid nanoparticle an overview sciencedirect topics.
Slns combine all the advantages of polymeric nanoparticles, fat emulsions and liposomes. Solid lipid nanoparticles thesis pdf development, characterization and evaluation of solid lipid nanoparticles as a potential. A new class of colloidal drug carriers, solid lipid nanoparticles slns, emerged in. The slmps were prepared by using two different solvent systems ethanol and waterethanol and lipid carriers dipalmitoylphosphatidylcholine dppc and cholesterol withwithout lleucine. In a first step, spherically shaped chitosan particles were produced by spray. Lorenzo rodriguez university of bologna consorzio tefarco innova interest in solid lipid microparticles slms is relatively recent and relates to the developments in the past. Solid lipid microparticles, drug delivery, lipidbased, drug encapsulation. Solid lipid nanoparticles sln are at the forefront of the rapidly developing field of. Then an overview of slm manufacturing compounds and techniques is presented. Production of lipid microparticles magnetically active by a.
Emulsions can be used as precursors for solid lipid particles preparation since lipids, that are solid at room temperature, can be heated 510 c above their melting point to obtain a liquid lipid that can be emulsified with water at the same temperature. The temperature should be regulated effectively to ensure the solid state of the. In multicellular organisms, microvesicles and other evs are found both in tissues in the interstitial space between cells and in many types of body fluids. Jun 11, 2014 the aim of this work was to develop dry powder inhaler dpi formulations of salbutamol sulfate ss by the aid of solid lipid microparticles slmps, composed of biocompatible phospholipids or cholesterol. Solid lipid nanoparticles slns are the first generation of lipidbased nanocarriers that are formulated from lipids, which are solid in the body temperature and. Slms combine many advantages of drug carrier systems. Slns combine all the advantages of polymeric nanoparticles, fat. Solid lipid nanoparticles a promising drug delivery system.
Preparation, characterization and evaluation of moisturizing. Formation of bioactivecarrier hollow solid lipid micro and. Solid lipid microparticles were produced from fhco using the particle formation unit shown in fig. Solid lipid nanoparticles are one of the novel potential colloidal carrier systems as alternative materials to polymers which is identical to oil in water emulsion for parenteral nutrition, but the liquid lipid of the emulsion has been replaced by a solid lipid shown on fig. Ir study of pure drug, stearic acid and drug loaded solid lipid microparticle were. Solid lipid nanoparticles preparation and characterization. Solid lipid nanoparticles slns have attracted increasing attention during recent years. There are different techniques for the preparation of solid lipid nanoand microparticles. These are the types of carriers which not only combine the. Lipid coated chitosan microparticles as protein carriers. All measure ments were performed in triplicate at a temperature of 25.
I velopments of the solid lipid nanoparticles slns according to the recent relevant literatures. The stability and biological activity of the drug must not be affected by the processing parameters employed in the fabrication of drugloaded microparticles. Almeida research institute for medicines and pharmaceutical sciences imed. Nanoparticles of magnetite were coated with lipids to form lipid nano and microparticles by a modifiedpgss technique carried out at moderate temperature. Solid lipid nanoparticles and polymeric nanocapsules are carrier systems that offer advantages including changes in the release profiles of. A solid lipid nanoparticle is typically spherical with an average diameter between 10 and nanometers. Solid lipid microparticles slms combine the advantages of different traditional carriers.
Where ee is entrapment efficiency, wa stands for the mass of. Lipid nanoparticles, oral drug delivery introduction nanotechnology is the most promising technology that is used today. Preparation and characterization of solid lipid nanoparticles. Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine, and research, as well as in other varied sciences. Journal of global trends in pharmaceutical sciences. Comparative study of sustainedrelease lipid microparticles. Solid lipid nanoparticles and nanostructured lipid carriers as novel. Formation of solid lipid microparticles from fully.
The ability to incorporate drugs into nanoparticles offers a new prototype in drug delivery thus realizing the dual goal of both controlled release and sitespecific drug delivery. A simple and green process based on supercritical carbon dioxide scco 2 technology was used to produce solid lipid microparticles from fully hydrogenated canola oil fhco. The particle formation unit was designed and custom built in our laboratory. Due to their unique size dependent properties, lipid nanoparticles offer possibility to develop new therapeutics. Slns combine the advantages and avoid the disadvantages of the other colloidal carriers liposomes, emulsions, and polymeric micro and nanoparticles 8. The supernatant was then diluted with methanol and analyzed by uvvis spectrophotometer at 233 nm using a model 71, electronics india. Formulation of inhalable lipidbased salbutamol sulfate. The tests were performed in triplicate, with the results shown being the average of the obtained values. Preparation and characterization of rizatriptan loaded solid. Jan 01, 2008 read solid lipid microparticles containing watersoluble compounds of different molecular mass.
These particles can be composed of different types of solid lipids, such as glycerides, waxes, and fatty acids, and stabilized by a wide range of surfactants. Please cite this article in press as umeyo r ce et al. These solid lipid microparticles are then dispersed in cold surfactant solution. In the following years, extensive work and experiments with solid lipids resulted in the invention of lipid based solid particles in the submicron range by the groups of westesen, muller and gasco 2 4. The prepared lipid microparticles are then dispersed in a cold emulsifier solution at or below room temperature. The drug is dissolved, dispersed, or solubilized in the hot melted lipid followed by cooling to room temperature. The lipid core is stabilized by surfactants emulsifiers. The wordcoacervationcomes from the latinacervus, meaning aggregation, and the prefixco,signifying the preceding union of the colloidal particles. It has been proposed that slns combine the advantages of traditional. Aspirinloaded solid lipid microparticles slms were formulated by hot homogenization and.
The effects of pressure 122, 211 and 300 bar and nozzle diameter 0. Determination of ibuprofen content using uvvis spectrophotometry for the determination of ibuprofen content in solid dispersions and lipid microparticles, 75 mg of each sample. Aspirinloaded solid lipid microparticles slms were formulated by hot homogenization and analysed for their encapsulation efficiency ee%, in vitro release, particle size, antiinflammatory and ulcer inhibition properties. Solid lipid nanoparticles sln, colloidal drug carriers, homogenization, tem, pcs, biodistribution. Then this presuspension is homogenized at or below room temperature, the gravitation force is strong. The entrapment efficacy of nanoparticle was calculated as follows. It has been proposed that slns combine the advantages of traditional colloidal. Techniques for the preparation of solid lipid nano and. Basic formulation of sln contained 10% of hydrogenated palm oil softisan 154 and hydrogenated lecithin lipid matrix, 1% oleyl alcohol, 0. The aim of the present study is to prepare and characterize rizatriptan loaded solid lipid nanoparticles slns. The lipid microparticles are then suspended in a cold aqueous surfactant solution to obtain a presuspension. They combine many advantages of drug carrier systems.
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