Jan 01, 2008 read solid lipid microparticles containing watersoluble compounds of different molecular mass. These solid lipid microparticles are then dispersed in cold surfactant solution. Solid lipid nanoparticles authorstream presentation. Microemulsion based method slns can be produced by microemulsification of molten lipids, as the internal phase and subsequent dispersion of the microemulsion in aqueous medium under mechanical stirring.
Journal of global trends in pharmaceutical sciences. The particle formation unit was designed and custom built in our laboratory. Slns combine all the advantages of polymeric nanoparticles, fat. Emulsions can be used as precursors for solid lipid particles preparation since lipids, that are solid at room temperature, can be heated 510 c above their melting point to obtain a liquid lipid that can be emulsified with water at the same temperature. Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine, and research, as well as in other varied sciences. In multicellular organisms, microvesicles and other evs are found both in tissues in the interstitial space between cells and in many types of body fluids. Preparation and characterization of solid lipid nanoparticles. The stability and biological activity of the drug must not be affected by the processing parameters employed in the fabrication of drugloaded microparticles. Formulation and evaluation of solid lipid nanoparticle sln. Production, characterisation and release profiles, food research international on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Aspirinloaded solid lipid microparticles slms were formulated by hot homogenization and. The entrapment efficacy of nanoparticle was calculated as follows. The drug containing solid lipid is milled bymeans of mortar or ball mill to micron size 50100 micron and these microparticles aredispersed in chilled emulsifier solution yielding a presuspension.
Therefore, the lipid magnetic particles produced by our modifiedpgss process have properties which are suitable for future use in biomedical application. The ability to incorporate drugs into nanoparticles offers a new prototype in drug delivery thus realizing the dual goal of both controlled release and sitespecific drug delivery. Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research, as well as in other varied sciences. In the following years, extensive work and experiments with solid lipids resulted in the invention of lipid based solid particles in the submicron range by the groups of westesen, muller and gasco 2 4. Preparation, characterization and evaluation of moisturizing. Slms combine many advantages of drug carrier systems. Please cite this article in press as umeyo r ce et al. The effects of pressure 122, 211 and 300 bar and nozzle diameter 0. I velopments of the solid lipid nanoparticles slns according to the recent relevant literatures. Formation of bioactivecarrier hollow solid lipid micro and. This study assessed the feasibility of using solid lipid nanoparticles for ocular delivery of voriconazole. Solid lipid nanoparticles slns are the first generation of lipidbased nanocarriers that are formulated from lipids, which are solid in the body temperature and.
They combine many advantages of drug carrier systems. The yield of microparticles should have the desired size range and the drug encapsulation efficiency should be high. Then this presuspension is homogenized at or below room temperature, the gravitation force is strong. Preparation and characterization of rizatriptan loaded solid. Slns combine all the advantages of polymeric nanoparticles, fat emulsions and liposomes. Comparative study of sustainedrelease lipid microparticles. A simple and green process based on supercritical carbon dioxide scco 2 technology was used to produce solid lipid microparticles from fully hydrogenated canola oil fhco. The lipid core is stabilized by surfactants emulsifiers. Where ee is entrapment efficiency, wa stands for the mass of. The temperature should be regulated effectively to ensure the solid state of the. The lipid microparticles are then suspended in a cold aqueous surfactant solution to obtain a presuspension. In a first step, spherically shaped chitosan particles were produced by spray. All components were weighted into sealed containers and heated to 80 c.
Techniques for the preparation of solid lipid nano and. It has been proposed that slns combine the advantages of traditional. Determination of ibuprofen content using uvvis spectrophotometry for the determination of ibuprofen content in solid dispersions and lipid microparticles, 75 mg of each sample. Due to their unique size dependent properties, lipid nanoparticles offer possibility to develop new therapeutics. It has been proposed that slns combine the advantages of traditional colloidal. A solid lipid nanoparticle is typically spherical with an average diameter between 10 and nanometers. Lipid nanoparticles, oral drug delivery introduction nanotechnology is the most promising technology that is used today. All measure ments were performed in triplicate at a temperature of 25. Design and evaluation of voriconazole loaded solid lipid. Solid lipid nanoparticles slns serve as an alternative carrier system for traditional colloidal carriers like polymeric microparticles, nanoparticles, liposomes and emulsions. Ir study of pure drug, stearic acid and drug loaded solid lipid microparticle were. The invention is related to compositions which can be used as dermal formulations for supporting the skin to restore normal conditions in case of e.
There are different techniques for the preparation of solid lipid nanoand microparticles. These are the types of carriers which not only combine the. The aim of the present study is to prepare and characterize rizatriptan loaded solid lipid nanoparticles slns. Solid lipid nanoparticles sln, colloidal drug carriers, homogenization, tem, pcs, biodistribution. These particles can be composed of different types of solid lipids, such as glycerides, waxes, and fatty acids, and stabilized by a wide range of surfactants.
The tests were performed in triplicate, with the results shown being the average of the obtained values. Systemic administration of voriconazole is associated with side effects including visual and hepatic abnormalities. The prepared lipid microparticles are then dispersed in a cold emulsifier solution at or below room temperature. Nanoparticles of magnetite were coated with lipids to form lipid nano and microparticles by a modifiedpgss technique carried out at moderate temperature. Solid lipid nanoparticles slns have attracted increasing attention during recent years. The supernatant was then diluted with methanol and analyzed by uvvis spectrophotometer at 233 nm using a model 71, electronics india. Solid lipid nanoparticles thesis pdf development, characterization and evaluation of solid lipid nanoparticles as a potential. Rizatriptan loaded sln were prepared by modified solvent injection method and characterized for shape, surface morphology, particle size, and drug entrapment. Formulation, preparation, characterisation, drug release. Us20120128777a1 compositions containing lipid micro or. Solid lipid nanoparticle an overview sciencedirect topics.
Then the drug lipid mixture is rapidlycooled either by means of liquid nitrogen or dry ice. Solid lipid nanoparticles sln, colloidal drug carriers, homogenization, tem, pcs, biodistribution, targeting. Specific objectives were to develop hollow solid lipid micro and nanoparticles using scco 2 technology, and to load the hollow solid lipid micro and nanoparticles with essential oil to develop food grade freeflowing powder. Solid lipid nanoparticles are one of the novel potential colloidal carrier systems as alternative materials to polymers which is identical to oil in water emulsion for parenteral nutrition, but the liquid lipid of the emulsion has been replaced by a solid lipid shown on fig. First, the advantages of slms compared with other drug carrier systems are listed. Formulation and characterization of hydrochlorothiazide solid. Solid lipid nanoparticles sln are a new generation of drug delivery systems being exploited for several drugs since the nineties. Solid lipid microparticles, drug delivery, lipidbased, drug encapsulation. Then an overview of slm manufacturing compounds and techniques is presented. Slns combine the advantages and avoid the disadvantages of the other colloidal carriers liposomes, emulsions, and polymeric micro and nanoparticles 8. Slns combine the advantages and avoid the drawbacks. Preparation, characterization and evaluation of moisturizing and uv protecting effects of topical solid lipid nanoparticles 685 and zeta potential of the sln formulations.
Due to their unique size dependent properties, lipid nanoparticles offer possibilities to develop new therapeutics. Solid lipid nanoparticles and polymeric nanocapsules are carrier systems that offer advantages including changes in the release profiles of bioactive compounds and their transfer to the site of. Solid lipid nanoparticles sln are at the forefront of the rapidly developing field of. Basic formulation of sln contained 10% of hydrogenated palm oil softisan 154 and hydrogenated lecithin lipid matrix, 1% oleyl alcohol, 0. Solid lipid microparticles slms combine the advantages of different traditional carriers.
Slns act as a new colloidal drug carrier for intravenous applications. The lipid matrix itself determines the particles pharmaceutical properties as it is the structure that stores, transports and releases the drug. Solid lipid nanoparticles and polymeric nanocapsules are carrier systems that offer advantages including changes in the release profiles of. Jun 11, 2014 the aim of this work was to develop dry powder inhaler dpi formulations of salbutamol sulfate ss by the aid of solid lipid microparticles slmps, composed of biocompatible phospholipids or cholesterol. Solid lipid nanoparticles and nanostructured lipid carriers as novel. These lipid microparticles are dispersed in a cold surfactant solution yielding a presuspension and homogenized at or below room. These lipid nanoparticles are known as solid lipid nanoparticles slns, which are attracting wide attention of formulators worldwide 2. Solid lipid nanoparticles preparation and characterization. Slns are colloidal carriers developed in the last decade as an alternative system to the existing traditional carriers emulsions, liposomes and polymeric nanoparticles. Lipid coated chitosan microparticles as protein carriers. The resultant substance is then ground to obtain lipid microparticles 50100. The drug is dissolved, dispersed, or solubilized in the hot melted lipid followed by cooling to room temperature. Voriconazole is a secondgeneration antifungal agent with excellent broad spectrum of antifungal activity commercially available for oral and intravenous administration.
Solid lipid nanoparticles a promising drug delivery system. Formulation and release characteristics of zidovudine bioline. Aspirinloaded solid lipid microparticles slms were formulated by hot homogenization and analysed for their encapsulation efficiency ee%, in vitro release, particle size, antiinflammatory and ulcer inhibition properties. The slmps were prepared by using two different solvent systems ethanol and waterethanol and lipid carriers dipalmitoylphosphatidylcholine dppc and cholesterol withwithout lleucine. Solid lipid nanoparticles sln are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery and research. An effective lipid based technology for controlled drug delivery. Production of lipid microparticles magnetically active by a. Microvesicles ectosomes, or microparticles are a type of extracellular vesicle ev that are released from the cell membrane. Formulation of inhalable lipidbased salbutamol sulfate. Solid lipid microdispersions slms based on pegylated solidified. Solid lipid microparticles were produced from fhco using the particle formation unit shown in fig. A new class of colloidal drug carriers, solid lipid nanoparticles slns, emerged in. The purpose of this study was to improve the solubilization, bioavailability, and permeability of hydrochlorothiazide hctz by the formulation and characterization of hctz solid lipid microparticles slms based on fat derived from irvingia gabonensis var.
Formation of solid lipid microparticles from fully. Slms combine the advantages of different traditional carriers. The wordcoacervationcomes from the latinacervus, meaning aggregation, and the prefixco,signifying the preceding union of the colloidal particles. The term coacervationwas suggested for the first time by two dutch scientists38. Lorenzo rodriguez university of bologna consorzio tefarco innova interest in solid lipid microparticles slms is relatively recent and relates to the developments in the past.
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